Abstract
Study objective
To study associations between nighttime sleep characteristics and time to pregnancy.
Methods
Pregnant people age ≥18 years and<18 weeks’ gestation were recruited from 3 New York
University Grossman School of Medicine affiliated hospitals in Manhattan and Brooklyn
(n = 1428) and enrolled into the New York University Children’s Health and Environment
Study. Participants in the first trimester of pregnancy were asked to recall their
time to pregnancy and their sleep characteristics in the 3 months before conception.
Results
Participants who reported sleeping<7 hours per night tended to have shorter time to
pregnancy than those who slept 7-9 hours per night (adjusted fecundability odds ratio = 1.16,
95% confidence interval: 0.94, 1.41). Participants with a sleep midpoint of 4 AM or
later tended to have longer time to pregnancy compared with those with earlier sleep
midpoints (before 4 AM) (adjusted fecundability odds ratio = 0.88, 95% confidence
interval: 0.74, 1.04). When stratified by sleep midpoint, sleeping<7 hours was significantly
associated with shorter time to pregnancy only among those whose sleep midpoint was
before 4 AM (adjusted fecundability odds ratio = 1.33, 95% confidence interval: 1.07,
1.67).
Conclusions
The association of sleep duration with time to pregnancy was modified by chronotype,
suggesting that both biological and behavioral aspects of sleep may influence fecundability.
Keywords
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Article info
Publication history
Published online: April 11, 2023
Accepted:
February 7,
2023
Received in revised form:
December 19,
2022
Received:
August 22,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 National Sleep Foundation. Published by Elsevier Inc. All rights reserved. All rights reserved.
