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Review Article| Volume 8, ISSUE 6, P593-600, December 2022

Call to action: Addressing sleep disturbances, a hallmark symptom of PTSD, for refugees, asylum seekers, and internally displaced persons

  • Yuwen Cynthia Jou
    Affiliations
    Harvard Extension School, Cambridge, Massachusetts, USA
    Search for articles by this author
  • Edward F. Pace-Schott
    Correspondence
    Corresponding author: Edward F Pace-Schott, Harvard Medical School, Massachusetts General Hospital - East, CNY 149 13th St., Charlestown, MA 02129, USA. Tel.: 508-523-4288.
    Affiliations
    Harvard Extension School, Cambridge, Massachusetts, USA

    Massachusetts General Hospital, Department of Psychiatry, Charlestown, Massachusetts, USA

    Harvard Medical School, Department of Psychiatry, Charlestown, Massachusetts, USA

    Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA
    Search for articles by this author
Published:October 26, 2022DOI:https://doi.org/10.1016/j.sleh.2022.09.003

      Abstract

      Sleep difficulty is a recognized hallmark symptom of post-traumatic stress disorder (PTSD) yet often remains an enduring and neglected problem post-treatment. Around 4.4%- 88.0% of refugees, asylum seekers, and internally displaced persons report PTSD, of which 39%- 99% report sleep difficulties. These percentages substantially exceed those of the general population. Yet there has been a lack of research examining evidence-based stand-alone and add-on treatments for PTSD and related sleep disturbances among this population. Barriers to treatment encountered by this population often vary by their legal status or location, but generally include lack of access due to insufficient evidence-based treatments or mental health practitioner shortages, lack of psychoeducation on mental health, cultural stigma, language barriers, situational instability, and racial bias. The refugee population has been on the rise over the past 10 years, and the United Nations estimated the recent Ukraine-Russia conflict would lead to an additional 12 million people needing humanitarian assistance inside Ukraine and more than 6.9 million refugees fleeing to neighboring countries in the coming months. Given that refugees, asylum seekers, and internally displaced persons repeatedly encounter barriers to mental health care specific to their predicament, interventions designed to accommodate their situation are imperative for improving their sleep and mental health. We therefore call for there to be more research on integrative programs incorporating evidence-based treatments that allow for scalability, adaptability, and rapid dissemination to maximize impact in this population. Further, we encourage trainings among clinicians and researchers to increase knowledge and confidence in working with this population.

      Keywords

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      Reference

      1. UNHCR. (2022, March 1). UN seeks US$1.7 billion as humanitarian needs soar in Ukraine and neighbouring countries. UNHCR. Available at: https://www.unhcr.org/ua/en/43001-un-seeks-us43001-43007-billion-as-humanitarian-needs-soar-in-ukraine-and-neighbouring-countries.html. Accessed April 22, 2022

        • Byrow Y.
        • Pajak R.
        • Specker P.
        • Nickerson A.
        Perceptions of mental health and perceived barriers to mental health help-seeking amongst refugees: a systematic review.
        Clin Psychol Rev. 2020; 75101812
        • Due C.
        • Green E.
        • Ziersch A.
        Psychological trauma and access to primary healthcare for people from refugee and asylum-seeker backgrounds: a mixed methods systematic review.
        Int J Mental Health Syst. 2020; 14: 71https://doi.org/10.1186/s13033-020-00404-4
        • Silove D.
        • Ventevogel P.
        • Rees S.
        The contemporary refugee crisis: an overview of mental health challenges.
        World Psychiatry. 2017; 16: 130-139
        • Benjet C.
        • Bromet E.
        • Karam E.G.
        • Kessler R.C.
        • Mclaughlin K.A.
        • Ruscio A.M.
        • et al.
        The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium.
        Psychol Med. 2016; 46: 327-343
        • Javanbakht A.
        • Grasser L.R.
        Biological psychiatry in displaced populations: what we know, and what we need to begin to learn.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2022;
        • Fazel M.
        • Wheeler J.
        • Danesh J.
        Prevalence of serious mental disorder in 7000 refugees resettled in western countries: a systematic review.
        Lancet. 2005; 365: 1309-1314
        • Bogic M.
        • Njoku A.
        • Priebe S.
        Long-term mental health of war-refugees: a systematic literature review.
        BMC Int Health Hum Rights. 2015; 15: 29https://doi.org/10.1186/s12914-015-0064-9
        • Turrini G.
        • Purgato M.
        • Ballette F.
        • Nosè M.
        • Ostuzzi G.
        • Barbui C.
        Common mental disorders in asylum seekers and refugees: umbrella review of prevalence and intervention studies.
        Int J Ment Health Syst. 2017; 11: 51
        • Lies J.
        • Mellor A.
        • Jobson L.
        • Drummond S.P.A.
        Prevalence of sleep disturbance and its relationships with mental health and psychosocial issues in refugees and asylum seekers attending psychological services in Australia.
        Sleep Health. 2019; 5: 335-343
        • Richter K.
        • Baumgärtner L.
        • Niklewski G.
        • et al.
        Sleep disorders in migrants and refugees: a systematic review with implications for personalized medical approach.
        EPMA J. 2020; 11: 251-260
        • Lies J.
        • Drummond S.P.A.
        • Jobson L.
        Longitudinal investigation of the relationships between trauma exposure, post-migration stress, sleep disturbance, and mental health in Syrian refugees.
        Eur J Psychotraumatol. 2020; 111825166
        • Ross R.J.
        • Ball W.A.
        • Sullivan K.A.
        • Caroff S.N.
        Sleep disturbance as the hallmark of posttraumatic stress disorder.
        Am J Psychiatry. 1989; 146: 697-707
        • Pigeon W.R.
        • Campbell C.E.
        • Possemato K.
        • Ouimette P.
        Longitudinal relationships of insomnia, nightmares, and PTSD severity in recent combat veterans.
        J Psychosom Res. 2013; 75: 546-550
        • Mysliwiec V.
        • Brock M.S.
        • Creamer J.L.
        • O'Reilly B.M.
        • Germain A.
        • Roth B.J.
        Trauma associated sleep disorder: a parasomnia induced by trauma.
        Sleep Med Rev. 2018; 37: 94-104https://doi.org/10.1016/j.smrv.2017.01.004
        • Freeman D.
        • Sheaves B.
        • Waite F.
        • Harvey A.G.
        • Harrison P.J.
        Sleep disturbance and psychiatric disorders.
        Lancet Psychiatry. 2020; 7: 628-637
        • Germain A.
        sleep disturbances as the hallmark of PTSD: where are we now?.
        Am J Psychiatry. 2013; 170: 372-382
        • Hertenstein E.
        • Feige B.
        • Gmeiner T.
        • et al.
        Insomnia as a predictor of mental disorders: a systematic review and meta-analysis.
        Sleep Med Rev. 2019; 43: 96-105
        • Pace-Schott E.F.
        • Germain A.
        • Milad M.R.
        Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory.
        Biol Mood Anxiety Disord. 2015; 5: 3
        • Charney M.E.
        • Hellberg S.N.
        • Bui E.
        • Simon N.M.
        Evidenced-based treatment of posttraumatic stress disorder: an updated review of validated psychotherapeutic and pharmacological approaches.
        Harv Rev Psychiatry. 2018; 26: 99-115
        • Lambert J.E.
        • Alhassoon O.M.
        Trauma-focused therapy for refugees: meta-analytic findings.
        J Couns Psychol. 2015; 62: 28-37
        • Turrini G.
        • Tedeschi F.
        • Cuijpers P.
        • et al.
        A network meta-analysis of psychosocial interventions for refugees and asylum seekers with PTSD.
        BMJ Global Health. 2021; 6 (029)e005029
        • Mclean C.P.
        • Levy H.C.
        • Miller M.L.
        • Tolin D.F.
        Exposure therapy for PTSD: a meta-analysis.
        Clin Psychol Rev. 2022; 91102115
        • Mørkved N.
        • Hartmann K.
        • Aarsheim L.M.
        • et al.
        A comparison of narrative exposure therapy and prolonged exposure therapy for PTSD.
        Clin Psychol Rev. 2014; 34: 453-467
        • Gutner C.A.
        • Casement M.D.
        • Stavitsky Gilbert K.
        • Resick P.A
        Change in sleep symptoms across cognitive processing therapy and prolonged exposure: a longitudinal perspective.
        Behav Res Ther. 2013; 51: 817-822
        • Larsen S.E.
        • Bellmore A.
        • Gobin R.L.
        • Holens P.
        • Lawrence K.A.
        • Pacella-LaBarbara M.L.
        An initial review of residual symptoms after empirically supported trauma-focused cognitive behavioral psychological treatment.
        J Anxiety Disord. 2019; 63: 26-35
        • Larsen S.E.
        • Fleming C.J.E.
        • Resick P.A.
        Residual symptoms following empirically supported treatment for PTSD.
        Psychol Trauma. 2019; 11: 207-215
        • Schnurr P.P.
        • Lunney C.A.
        Residual symptoms following prolonged exposure and present-centered therapy for PTSD in female veterans and soldiers.
        Depress Anxiety. 2019; 36: 162-169
        • Walters E.M.
        • Jenkins M.M.
        • Nappi C.M.
        • et al.
        The impact of prolonged exposure on sleep and enhancing treatment outcomes with evidence-based sleep interventions: a pilot study.
        Psychol Trauma. 2020; 12: 175-185
        • Zayfert C.
        • DeViva J.C.
        Residual insomnia following cognitive behavioral therapy for PTSD.
        J Trauma Stress. 2004; 17: 69-73
        • Haynes P.L.
        • Skobic I.
        • Epstein D.R.
        • et al.
        Cognitive processing therapy for posttraumatic stress disorder is associated with negligible change in subjective and objective sleep.
        Behav Sleep Med. 2020; 18: 809-819
        • Pruiksma K.E.
        • Taylor D.J.
        • Wachen J.S.
        • et al.
        Residual sleep disturbances following PTSD treatment in active duty military personnel.
        Psychol Trauma. 2016; 8: 697-701
        • Bernardi J.
        • Dahiya M.
        • Jobson L.
        Culturally modified cognitive processing therapy for Karen refugees with posttraumatic stress disorder: a pilot study.
        Clin Psychol Psychother. 2019; 26: 531-539
        • Schulz P.M.
        • Resick P.A.
        • Huber L.C.
        • Griffin M.G.
        The effectiveness of cognitive processing therapy for PTSD with refugees in a community setting.
        Cogn Behav Pract. 2006; 13: 322-331
        • Wright A.
        • Reisig A.
        • Cullen B.
        Efficacy and cultural adaptations of narrative exposure therapy for trauma-related outcomes in refugees/asylum-seekers: a systematic review and meta-analysis.
        J Behav Cogn Ther. 2020; 30: 301-314
        • Sloan D.M.
        • Marx B.P.
        • Lee D.J.
        • Resick P.A.
        A brief exposure-based treatment vs cognitive processing therapy for posttraumatic stress disorder: a randomized noninferiority clinical trial.
        JAMA Psychiatry. 2018; 75: 233-239
        • Taylor D.J.
        • Pruiksma K.E.
        Cognitive and behavioral therapy for insomnia (CBT-I) in psychiatric populations: a systematic review.
        Int Rev Psychiatry. 2014; 26: 205-213
        • Miller K.E.
        • Brownlow J.A.
        • Gehrman P.R.
        Sleep in PTSD: treatment approaches and outcomes.
        Curr Opin Psychol. 2020; 34: 12-17https://doi.org/10.1016/j.copsyc.2019.08.017
        • Swift N.
        • Stewart R.
        • Andiappan M.
        • Smith A.
        • Espie C.A.
        • Brown J.S.L.
        The effectiveness of community day-long CBT-I workshops for participants with insomnia symptoms: a randomized controlled trial.
        J Sleep Res. 2012; 21: 270-280
        • Ritterband L.M.
        • Thorndike F.P.
        • Ingersoll K.S.
        • et al.
        Effect of a web-based cognitive behavior therapy for insomnia intervention with 1-year follow-up: a randomized clinical trial.
        JAMA Psychiatry. 2017; 74: 68-75
        • Edinger J.D.
        • Sampson W.S.
        A primary care “Friendly” cognitive behavioral insomnia therapy.
        Sleep. 2003; 26: 177-182
        • Pigeon W.R.
        • Funderburk J.S.
        • Cross W.
        • Bishop T.M.
        • Crean H.F.
        Brief CBT for insomnia delivered in primary care to patients endorsing suicidal ideation: a proof-of-concept randomized clinical trial.
        Transl Behav Med. 2019; 9: 1169-1177
        • Troxel W.M.
        • Germain A.
        • Buysse D.J.
        Clinical management of insomnia with brief behavioral treatment (BBTI).
        Behav Sleep Med. 2012; 10: 266-279https://doi.org/10.1080/15402002.2011.607200
        • Talbot L.S.
        • Maguen S.
        • Metzler T.J.
        • et al.
        Cognitive behavioral therapy for insomnia in posttraumatic stress disorder: a randomized controlled trial.
        Sleep. 2014; 37: 327-341
        • Casement M.D.
        • Swanson L.M.
        A meta-analysis of imagery rehearsal for post-trauma nightmares: effects on nightmare frequency, sleep quality, and posttraumatic stress.
        Clin Psychol Rev. 2012; 32: 566-574
        • El-Solh A.A.
        Management of nightmares in patients with posttraumatic stress disorder: current perspectives.
        Nat Sci Sleep. 2018; 10: 409-420
        • Cook J.M.
        • Harb G.C.
        • Gehrman P.R.
        • et al.
        Imagery rehearsal for posttraumatic nightmares: a randomized controlled trial.
        J Trauma Stress. 2010; 23: 553-563
        • Harb G.C.
        • Cook J.M.
        • Phelps A.J.
        • et al.
        Randomized controlled trial of imagery rehearsal for posttraumatic nightmares in combat veterans.
        J Clin Sleep Med. 2019; 15: 757-767
        • Pruiksma K.E.
        • Cranston C.C.
        • Rhudy J.L.
        • Micol R.L.
        • Davis J.L.
        Randomized controlled trial to dismantle exposure, relaxation, and rescripting therapy (ERRT) for trauma-related nightmares.
        Psychol Trauma. 2018; 10: 67-75
        • Colvonen P.J.
        • Straus L.D.
        • Stepnowsky C.
        • Mccarthy M.J.
        • Goldstein L.A.
        • Norman S.B.
        Recent advancements in treating sleep disorders in co-occurring PTSD.
        Current Psychiatry Reports. 2018; 20: 48https://doi.org/10.1007/s11920-018-0916-9
      2. Edinger JD; Morin CM; Wilfred R. Pigeon WR (2022) Pharmacologic treatment III: sequenced and combined psychologic and pharmacologic treatments for insomnia. In: Kryger MH, Roth T, Dement WC, editors, Principles and Practice of Sleep Medicine, 7th edition. Philadelphia: Elsevier; 2021: 922-934

        • Galovski T.E.
        • Harik J.M.
        • Blain L.M.
        • Elwood L.
        • Gloth C.
        • Fletcher T.D.
        Augmenting cognitive processing therapy to improve sleep impairment in PTSD: a randomized controlled trial.
        J Consult Clin Psychol. 2016; 84: 167-177
        • Galovski T.E.
        • Monson C.
        • Bruce S.E.
        • Resick P.A.
        Does cognitive-behavioral therapy for PTSD improve perceived health and sleep impairment?.
        J Trauma Stress. 2009; 22: 197-204
        • Gunn H.E.
        • Tutek J.
        • Buysse D.J.
        Brief behavioral treatment of insomnia.
        Sleep Med Clin. 2019; 14: 235-243
        • Krakow B.
        • Haynes P.L.
        • Warner T.D.
        • et al.
        Nightmares, insomnia, and sleep-disordered breathing in fire evacuees seeking treatment for posttraumatic sleep disturbance.
        J Trauma Stress. 2004; 17: 257-268
        • Pigeon W.R.
        • Heffner K.L.
        • Crean H.
        • et al.
        Responding to the need for sleep among survivors of interpersonal violence: a randomized controlled trial of a cognitive-behavioral insomnia intervention followed by PTSD treatment.
        Contemp Clin Trials. 2015; 45 (Pt B): 252-260
        • Ulmer C.S.
        • Edinger J.D.
        • Calhoun P.S.
        A multi-component cognitive-behavioral intervention for sleep disturbance in veterans with PTSD: a pilot study.
        J Clin Sleep Med. 2011; 7: 57-68
        • Sandahl H.
        • Baandrup L.
        • Vindbjerg E.
        • Jennum P.
        • Carlsson J.
        Social zeitgebers and circadian dysrhythmia are associated with severity of symptoms of PTSD and depression in trauma-affected refugees.
        Eur Arch Psychiatry Clin Neurosci. 2021; 271: 1319-1329
        • Poschmann I.S.
        • Palic S.
        • Sandahl H.
        • Berliner P.
        • Carlsson J.
        Imagery rehearsal therapy for trauma-affected refugees – a case series.
        Int J Dream Res. 2021; 14: 121-130
        • Krystal J.H.
        • Davis L.L.
        • Neylan T.C.
        • et al.
        It is time to address the crisis in the pharmacotherapy of posttraumatic stress disorder: a consensus statement of the PTSD psychopharmacology working group.
        Biol Psychiatry. 2017; 82: e51-e59
      3. Hendrickson, R. C., Millard, S. P., Pagulayan, K. F., Peskind, E. R., & Raskind, M. A. (2021). The relative effects of prazosin on individual PTSD Symptoms: evidence for pathophysiologically-related clustering. Chronic Stress, 5, 247054702097978.

        • Yücel D.E.
        • van Emmerik A.A.P.
        • Souama C.
        • Lancee J.
        Comparative efficacy of imagery rehearsal therapy and prazosin in the treatment of trauma-related nightmares in adults: a meta-analysis of randomized controlled trials.
        Sleep Med Rev. 2020; 50101248
        • Germain A.
        • Richardson R.
        • Moul D.E.
        • et al.
        Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans.
        J Psychosom Res. 2012; 72: 89-96
        • Raskind M.A.
        • Peskind E.R.
        • Chow B.
        • et al.
        Trial of prazosin for post-traumatic stress disorder in military veterans.
        N Engl J Med. 2018; 378: 507-517
        • Raskind M.A.
        • Millard S.P.
        • Petrie E.C.
        • et al.
        Higher pretreatment blood pressure is associated with greater posttraumatic stress disorder symptom reduction in soldiers treated with prazosin.
        Biol Psychiatry. 2016; 80: 736-742
        • Raskind M.A.
        • Peskind E.R.
        Prazosin for post-traumatic stress disorder.
        N Engl J Med. 2018; 378: 1649-1650
        • Boynton L.
        • Bentley J.
        • Strachan E.
        • Barbato A.
        • Raskind M.
        Preliminary findings concerning the use of prazosin for the treatment of posttraumatic nightmares in a refugee population.
        J Psychiatr Pract. 2009; 15: 454-459
        • Sonne C.
        • Carlsson J.
        • Bech P.
        • Mortensen E.L.
        Pharmacological treatment of refugees with trauma-related disorders: What do we know today?.
        Transcult Psychiatry. 2017; 54: 260-280
      4. Hegberg, N. J., Hayes, J. P., & Hayes, S. M. (2019). Exercise intervention in PTSD: a narrative review and rationale for implementation. Front Psychiatry, 10, 133.

        • Lederman O.
        • Ward P.B.
        • Firth J.
        • et al.
        Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis.
        J Psychiatr Res. 2019; 109: 96-106
        • Nilsson H.
        • Saboonchi F.
        • Gustavsson C.
        • Malm A.
        • Gottvall M.
        Trauma-afflicted refugees’ experiences of participating in physical activity and exercise treatment: a qualitative study based on focus group discussions.
        Euro J Psychotraumatol. 2019; 101699327
        • Jespersen K.V.
        • Vuust P.
        The effect of relaxation music listening on sleep quality in traumatized refugees: a pilot study.
        J Music Ther. 2012; 49: 205-229
        • Tol W.A.
        • Ager A.
        • Bizouerne C.
        • et al.
        Improving mental health and psychosocial well-being in humanitarian settings: reflections on research funded through R2HC.
        Confl Health. 2020; 14: 71https://doi.org/10.1186/s13031-020-00317-6
        • Alcántara C.
        • Giorgio Cosenzo L.
        • McCullough E.
        • Vogt T.
        • Falzon A.L.
        • Perez Ibarra I.
        Cultural adaptations of psychological interventions for prevalent sleep disorders and sleep disturbances: a systematic review of randomized controlled trials in the United States.
        Sleep Med Rev. 2021; 56101455
        • Ennis N.
        • Shorer S.
        • Shoval-Zuckerman Y.
        • Freedman S.
        • Monson C.M.
        • Dekel R.
        Treating posttraumatic stress disorder across cultures: a systematic review of cultural adaptations of trauma-focused cognitive behavioral therapies.
        J Clin Psychol. 2020; 76: 587-611
        • Hendrickx M.
        • Woodward A.
        • Fuhr D.C.
        • Sondorp E.
        • Roberts B.
        The burden of mental disorders and access to mental health and psychosocial support services in Syria and among Syrian refugees in neighboring countries: a systematic review.
        J Public Health. 2020; 42: e299-e310
        • Sandahl H.
        • Vindbjerg E.
        • Carlsson J.
        Treatment of sleep disturbances in refugees suffering from post-traumatic stress disorder.
        Transcult Psychiatry. 2017; 54: 806-823
        • Vermette D.
        • Shetgiri R.
        • Al Zuheiri H.
        • Flores G.
        Healthcare access for iraqi refugee children in texas: persistent barriers, potential solutions, and policy implications.
        J ImmigrMinor Health. 2015; 17: 1526-1536
        • Glass I.
        770: My lying eyes [Audio podcast].
        Am Life. 2022; (Podcast Available at:) (Accessed August 22, 2022)
        • Witte M.
        Ukrainian refugees face a more accommodating Europe, says Stanford scholar.
        Stanf News Serv. 2022; (Available at:) (Accessed August 22, 2022)
        • Gong-Guy E.
        • Cravens R.B.
        • Patterson T.E.
        Clinical issues in mental health service delivery to refugees.
        Am Psycholt. 1991; 46: 642-648
        • Schlechter P.
        • Hellmann J.H.
        • Wingbermühle P.
        • Morina N.
        Which psychological characteristics influence therapists' readiness to work with refugees?.
        Clin PsycholPsychother. 2021; 28: 334-344
        • Hinton D.
        • Lewis-Fernández R
        The cross-cultural validity of posttraumatic stress disorder: implications for DSM-5.
        Depress Anxiety. 2011; 28: 783-801
        • Marques, Robinaugh D.J.
        • LeBlanc N.J.
        • Hinton D
        Cross-cultural variations in the prevalence and presentation of anxiety disorders.
        Exp Rev Neurother. 2011; 11: 313-322
        • Segal S.P.
        • Khoury V.C.
        • Salah R.
        • Ghannam J.
        Unattended mental health needs in primary care: Lebanon's Shatila Palestinian Refugee Camp.
        Clin Med Insights. 2020; 11117955732096252
      5. UNHCRa. (2021). Refugee Data Finder. UNHCR. Available at: https://www.unhcr.org/refugee-statistics/. Accessed August 26, 2022.

        • Sandahl H.
        • Jennum P.
        • Baandrup L.
        • Lykke Morztensen E.
        • Carlsson J.
        Imagery rehearsal therapy and/or mianserin in treatment of refugees diagnosed with PTSD: Results from a randomized controlled trial.
        J Sleep Res. 2021; 30: e13276https://doi.org/10.1111/jsr.13276
      6. UNHCRb. (2022, August 26). Refugees from Ukraine recorded across Europe (since 23 August 2022). UNHCR. Available at: https://data2.unhcr.org/en/situations/ukraine. Accessed August 26, 2022

        • Nappi C.M.
        • Drummond S.P.
        • Hall J.M.
        Treating nightmares and insomnia in posttraumatic stress disorder: a review of current evidence.
        Neuropharmacology. 2012; 62: 576-585https://doi.org/10.1016/j.neuropharm.2011.02.029
        • Rousseau P.F.
        • Vallat R.
        • Coste O.
        • et al.
        Sleep parameters improvement in PTSD soldiers after symptoms remission.
        Sci Rep. 2021; 11: 8873https://doi.org/10.1038/s41598-021-88337-x
      7. UNHCRb. (2022, August 26). Refugees from Ukraine recorded across Europe (since 23 August 2022). UNHCR. Available at: https://data2.unhcr.org/en/situations/ukraine. Accessed August 26, 2022