Abstract
Objective
To explore the association between sleep duration and kidney stones among United States
adults.
Participants and methods
This cross-sectional study is based on National Health and Nutrition Examination Surveys
(NHANES) 2007-2018. Participants aged 20 years and above who self-reported history
of kidney stones and sleep duration were included. Weighted proportions, multivariable
analysis, and piecewise linear regression were used to evaluate the associations between
sleep duration and kidney stones, while adjusting for gender, age, race, poverty income
ratio, body mass index, education, marital status, trouble sleeping, smoking, alcohol
and some comorbidities. Stratified logistic regression models were used in subgroup
analyses and included all potential confounding factors above.
Results
Of the 34,190 participants, the overall weighted kidney stone prevalence was 9.73%,
weighted mean age was 47.67 ± 16.99 years, and mean sleep duration was 7.15 ± 1.44
hours. The fully adjusted multivariable model demonstrated that people with normal
(7-9 hours) and long (>9 hours) sleep duration had 17% and 20% lower odds of kidney
stone prevalence than people with short sleep duration (<7 hours), respectively. However,
fitting a smooth curve showed a nonlinear association between sleep duration and kidney
stones. A piecewise linear regression model showed that one hour longer sleep duration
was associated with 7% lower kidney stone prevalence for people with short sleep duration
and with 22% higher prevalence for participants with long sleep duration. However,
for people with normal sleep duration, increasing sleep duration was nonsignificantly
associated with lower prevalence of kidney stones. Subgroup analysis showed no significant
interaction effects.
Conclusions
There is a curvilinear relationship between sleep duration and kidney stones. Normal
sleep duration is associated with lower prevalence of kidney stones than short sleep
duration. This study provides new insight into potential strategies for the prevention
and treatment of kidney stones.
Keywords
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Article Info
Publication History
Published online: October 07, 2022
Accepted:
August 12,
2022
Received in revised form:
July 14,
2022
Received:
August 5,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
