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Prior sleep-wake behaviors are associated with mental health outcomes during the COVID-19 pandemic among adult users of a wearable device in the United States
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaInstitute for Breathing and Sleep, Austin Health, Melbourne, VIC, AustraliaDepartment of Psychiatry, Brigham & Women's Hospital, Boston, MA, USAFrancis Weld Peabody Society, Harvard Medical School, Boston, MA, USA
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USADivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, Boston, MA, USA
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USADivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, Boston, MA, USA
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaInstitute for Breathing and Sleep, Austin Health, Melbourne, VIC, AustraliaDivision of Medicine, University of Melbourne, Melbourne, VIC, Australia
Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaInstitute for Breathing and Sleep, Austin Health, Melbourne, VIC, AustraliaDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USADivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, Boston, MA, USA
To characterize objective sleep patterns among U.S. adults before and during the COVID-19 pandemic, and to assess for associations between adverse mental health symptoms and (1) sleep duration and (2) the consistency of sleep timing before and during the pandemic.
Design
Longitudinal objective sleep-wake data during January-June 2020 were linked with mental health and substance use assessments conducted during June 2020 for The COVID-19 Outbreak Public Evaluation (COPE) Initiative.
Setting
Adult users of WHOOP—a commercial, digital sleep wearable.
Participants
Adults residing in the U.S. and actively using WHOOP wearable devices, recruited by WHOOP, Inc.
Intervention
The COVID-19 pandemic and its mitigation.
Measurements
Anxiety or depression symptoms, burnout symptoms, and new or increased substance use to cope with stress or emotions.
Results
Of 4912 participants in the primary analytic sample (response rate, 14.9%), we observed acutely increased sleep duration (0.25 h or 15 m) and sleep consistency (3.51 points out of 100) and delayed sleep timing (onset, 18.7 m; offset, 36.6 m) during mid-March through mid-April 2020. Adjusting for demographic and lifestyle variables, participants with persistently insufficient sleep duration and inconsistent sleep timing had higher odds of adverse mental health symptoms and substance use in June 2020.
Conclusions
U.S. adult wearable users displayed increased sleep duration, more consistent sleep timing, and delayed sleep onset and offset times after the COVID-19 pandemic onset, with subsample heterogeneity. Associations between adverse mental health symptoms and pre- and mid-pandemic short sleep duration and inconsistent sleep timing suggest that these characteristics warrant further investigation as potential modifiable mental health and substance use risk factors.
Absent widespread testing or safe and effective coronavirus disease 2019 (COVID-19) vaccines in early 2020, stringent mitigation policies (eg, stay-at-home orders, business closures) were implemented in the United States and globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. Among the consequences of these measures were enhanced opportunities for the self-selection of sleep habits, resulting from work-at-home directives, reduced travel and commutes, school closures, and stay-at-home orders. Recognizing this opportunity, and the value of sleep health during an interval of profound disruption, the National Sleep Foundation published a Position Statement urging the public to follow healthy sleep habits and maintain regular sleep-wake schedules during the pandemic.
Estimated sleep duration before and during the COVID-19 pandemic in major metropolitan areas on different continents: observational study of smartphone app data.
Changes in health promoting behavior during COVID-19 physical distancing: utilizing wearable technology to examine trends in sleep, activity, and cardiovascular indicators of health.
have been used to report increased sleep duration and delayed sleep timing during the pandemic in the U.S. and other countries. More than half of 6882 participants from 59 countries who completed online surveys conducted during mid-April to early May 2020 reported that they had delayed their sleep timing, according to a study published by Yuksel et al. in Sleep Health.
Similarly, among approximately 1000 survey respondents in Argentina, Leone et al. found that participants slept longer and later on weekdays during the initial phase of Argentinian COVID-19 lockdowns compared with before the pandemic, and exhibited lower levels of social jetlag.
Using wearable data, a Sleep Health publication by Rezaei and Grandner revealed similar changes to the trajectories of sleep duration and timing among 163,524 active Fitbit users from 6 major U.S. cities.
Additionally, analysis of objective smartphone application users from 5 major metropolitan areas across 4 countries by Robbins et al. found that estimated sleep duration increased across regions. The authors observed a 14-minute increase in estimated sleep duration in March 2020 as compared with March 2019, and a 22-minute increase when comparing April 2020 with April 2019.
Estimated sleep duration before and during the COVID-19 pandemic in major metropolitan areas on different continents: observational study of smartphone app data.
Simultaneously, population-level surveillance studies revealed considerably elevated levels of adverse mental health symptoms and substance use among U.S. adults, including 3-4 times the prevalence of anxiety and depression symptoms and twice the prevalence of suicidal ideation in the second quarter of 2020 as compared to that of 2019.
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia.
Adverse mental health symptoms were disproportionately reported by younger adults, unpaid caregivers, essential workers, and persons with psychiatric or substance use conditions.
underscoring the importance of examining different sleep characteristics to inform strategies and interventions to improve population-level sleep health and patient-level clinical care. For example, evidence from the 2018 Behavioral Risk Factor Surveillance System data including 273,695 U.S. adults aged 18-64 years found that participants with an average sleep duration ≤6 h nightly had 2.5 times (95% CI, 2.3-2.7) the odds of frequent mental distress compared with individuals who slept >6 h nightly.
Separately, adjusting for sleep duration, a study of 451,025 individuals using multiple Mendelian Randomization techniques found robust evidence supporting early diurnal preference as protective for depression and wellbeing.
Finally, relationships between inconsistent sleep timing and adverse mental health are increasingly recognized, including with mood disorders, depression, wellbeing, and cognitive function.
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.
Too long, too short, or too variable? Sleep intraindividual variability and its associations with perceived sleep quality and mood in adolescents during naturalistically unconstrained sleep.
Objectively assessed sleep variability as an acute warning sign of suicidal ideation in a longitudinal evaluation of young adults at high suicide risk.
Indeed, during the initial phase of the COVID-19 pandemic, links between poor sleep and adverse mental health symptoms have been reported based on survey data,
However, most surveys have limited resolution of sleep-wake measurement (eg, daily logs or cross-sectional surveys vs 30-second epochs) and lack prepandemic data. Moreover, sleep health has several dimensions (duration, timing, quality, regularity) linked with mental health,
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.
Too long, too short, or too variable? Sleep intraindividual variability and its associations with perceived sleep quality and mood in adolescents during naturalistically unconstrained sleep.
To address these knowledge gaps, we examined objective sleep and mental health among U.S. users of a sleep wearable (WHOOP, Inc., Boston, Massachusetts) before and during the COVID-19 pandemic using comprehensive sets of mental health (symptoms of anxiety or depression, burnout, and substance use to cope with stress or emotions) and sleep variables (duration, sleep onset, sleep offset, consistency of sleep timing, and wakefulness during time in bed). We characterized multiple dimensions of sleep before and during the pandemic and explored associations between mental health and (1) sleep duration and (2) consistency of sleep timing. Regarding sleep patterns overall, given prior survey and wearable data on various samples during the pandemic, we hypothesized that during as compared with before the pandemic, participants would exhibit acutely increased sleep duration, delayed sleep timing, and increased sleep consistency, without reduced sleep efficiency. Regarding sleep and mental health, we hypothesized that reduced sleep duration and lesser sleep consistency would each be associated with anxiety or depression symptoms, new or increased substance use, and burnout symptoms.
Participants and methods
Study design and participant details
U.S. WHOOP users aged ≥18 years who had recorded 7 consecutive nocturnal sleep episodes prior to a prospective invitation were invited to participate in Internet-based surveys during June 24-30, 2020. The week was selected to align with a similar largescale, national survey administered through The COVID-19 Public Evaluation (COPE) Initiative to a demographically representative sample of U.S. adults.
Participants provided informed electronic consent prior to enrollment and agreed to allow their deidentified wearable data to be used for research purposes, as outlined in the WHOOP, Inc. Terms and Conditions. Investigators received anonymized survey responses, which were linked with wearable data using unique identifiers. The Monash University Human Research Ethics Committee reviewed and approved the study (#25280).
WHOOP measures
For this analysis, objective WHOOP variables included sleep duration in hours over 24 h intervals (calculated as the sum of nocturnal sleep episodes plus nap sleep episodes, detected automatically or manually
for daily use by accounting for recency in weighting of comparator sleep-wake episodes), sleep onset and offset, and wakefulness during time in bed (calculated as the difference between time in bed and time asleep, which is equivalent to sleep latency plus wake after sleep onset [WASO]). The WHOOP sleep consistency measure, like the SRI developed by Phillips et al.,
calculates the percentage of concordance of individuals being in the same state (asleep vs. awake) at different timepoints. Whereas the SRI compares 2 timepoints 24 h apart, WHOOP sleep consistency compares 24 h timepoints over a 4-day interval (eg, timepoint 1 [T1], T1 + 24 h, T1 + 48 h, T1 + 72 h), with comparisons of intervals further apart assigned progressively lower weights in calculating sleep consistency scores for a given timepoint.
Scores are converted to a 0%-100% scale, with higher consistency scores reflecting lower sleep timing variability.
Naps were included within 24 h sleep measures to avoid erroneously categorizing individuals with comparatively more nap sleep duration during versus before the pandemic as having slept less on the basis of relatively decreased nocturnal sleep duration, especially given evidence of increased frequency of napping during the pandemic.
Among 6 young, healthy participants, compared with polysomnography, both autodetected and manually entered WHOOP sleep measurements demonstrated high levels of agreement for 2-stage (sleep vs. wake) categorization, at 86% and 90%, respectively.
Among 12 young, healthy adults, compared with polysomnography, total sleep time recorded by WHOOP did not differ significantly (WHOOP mean, 358.7 ± 98.5 m, polysomnography mean, 350.4 ± 105.2 m, mean difference, 8.2 ± 32.9 m, P = .54). For 2-stage categorization, WHOOP demonstrated high levels of agreement with polysomnography and sensitivity to sleep (89% and 95%, respectively), and moderate specificity for wake and Cohen's kappa for chance-adjusted agreement (51% and 0.49, respectively).
Finally, among 32 young, healthy participants, WHOOP demonstrated low bias and precision errors (13.8 m and 17.8 m, respectively) for measuring sleep duration compared with polysomnography, and recorded a moderate intraclass correlation coefficient (0.67 ± 0.15).
The survey instrument was developed for The COPE Initiative (www.thecopeinitiative.org). Similar versions of the survey have been administered to adults in the U.S. and Australia to assess public attitudes, behaviors, and beliefs about the COVID-19 pandemic and its mitigation,
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia.
Demographic variables included in this analysis were age, sex, combined race and ethnicity, U.S. Census region, 2019 household income, highest education attainment, employment status, unpaid caregiver role, and political ideology. Age and sex were input upon WHOOP user registration. Age was categorized for the analysis as 18-29, 30-44, 45-64, or 65-plus years. Sex options were female or male. Within the survey, demographic variables included race and ethnicity (assessed separately and analyzed in the combined categories of non-Hispanic White, non-Hispanic Black, non-Hispanic Asian, non-Hispanic other race or multiple races, Hispanic or Latino of any race, or unknown), U.S. Census region (Northeast, Midwest, South, or West), 2019 household income in USD (categorized as <25,000, 25,000-49,999, 50,000-99,999, 100,000-199,999, ≥200,000, or unknown), highest education attainment (categorized as high school diploma or less, college or some college, bachelor's degree, professional degree, or unknown), employment status (categorized as employed as an essential worker, employed as a nonessential worker, unemployed, retired, or student only), unpaid caregiver role (categorized as yes, no, or unknown), and political ideology (categorized as very liberal, slightly liberal, neither liberal nor conservative, slightly conservative, very conservative, or either apolitical or unknown).
Additional measures included weekly days with ≥30 m of physical activity and with alcoholic beverage consumption, plus diurnal preference. Physical activity was assessed using a validated single-item physical activity measure.
Weekly alcoholic beverage consumption was analyzed by multiplying 7 by the answer to the following question: “How many alcoholic beverages did you consume on a typical day in the past week?” Diurnal preference was assessed using Item 19 of the Horne & Östberg Morningness-Eveningness questionnaire.
and past-month new or increased substance use to cope with stress or emotions. For the PHQ-4, participants who scored ≥3 out of 6 on the Generalized Anxiety Disorder (GAD-2) and Patient Health Questionnaire (PHQ-2) subscales were considered symptomatic for anxiety or depression, respectively.
Substance use was defined as use of “alcohol, legal or illegal drugs, or prescriptions drugs that are taken in a way not recommended by your doctor.” Participants were asked, “Have you started or increased using substances to help you cope with stress or emotions during the COVID-19 pandemic?”
Statistical Analysis
Study intervals were set as prepandemic (January1-March 12, 2020) and pandemic (March 13-June 30, 2020). For the sleep analysis, the pandemic interval was subdivided into the acute pandemic onset (March 13-April 12, 2020), and mid-pandemic (April 13-June 30, 2020) intervals. Participants with WHOOP data for ≥70% of nocturnal sleep episodes during the pre-pandemic, acute pandemic onset, and mid-pandemic intervals were included in the primary analytic sample. Participants in the primary analytic sample who completed the PHQ-4 were included in the mental health analytic subsample. Chi-square tests were used to assess for demographic differences between participants who did versus did not complete the PHQ-4, with statistical significance set at 2-sided P × 9 <.05 to account for nine comparisons (Bonferroni adjustment).
Means and standard deviations were calculated for each WHOOP variable for participants, overall and during each study interval. Paired t-tests were used to test for differences in mean values for sleep measures between the prepandemic and acute pandemic onset intervals, and between the prepandemic and mid-pandemic intervals. Statistical significance was set at 2-sided P × 10 <.05 and 95% confidence intervals were estimated at the 99.5% confidence level to account for 10 comparisons (Bonferroni adjustment). Continuous sleep measures were used to maximize resolution of the data.
Means and standard deviations were also calculated for each WHOOP variable for deciles of participants (n, 491) with the highest-magnitude changes in sleep measures comparing the prepandemic and pandemic intervals (ie, combined acute pandemic onset and mid-pandemic intervals). Among each decile, paired t-tests were used to test for differences in mean values between these intervals. Statistical significance was set at 2-sided P × 10 <.05 and 95% confidence intervals were estimated at the 99.5% confidence level to account for 10 comparisons (Bonferroni adjustment).
Finally, multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for each of the assessed adverse mental health symptoms (anxiety or depression symptoms, new or increased substance use, burnout symptoms) based on prepandemic and mid-pandemic WHOOP measures for sleep duration and sleep consistency. The mid-pandemic interval was chosen rather than the acute pandemic onset interval both because it was a more stable interval (following acute pandemic-related disruptions) and because it captured sleep more temporally proximate to the measurement of mental health.
Mean sleep duration during these intervals was categorized as <6 h, 6-7 h, or >7 h, with >7 h as the reference group reflecting optimal healthy sleep duration based on the Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society,
Consensus Conference Panel Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.
While a standard based on sleep consistency has not yet been established, more consistent sleep timing is generally associated with better health outcomes.
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.
Too long, too short, or too variable? Sleep intraindividual variability and its associations with perceived sleep quality and mood in adolescents during naturalistically unconstrained sleep.
Given the distribution of sleep consistency scores in the mental health sample (percentiles: 25th = 71.5; 50th = 76.3; 75th = 80.5), mean sleep consistency was categorized as <70, 70-80, or >80 out of 100, with >80 as the reference group reflecting optimal sleep consistency.
As there were 2 intervals and 3 categories for each variable, there were 9 possible combinations per variable (eg, sleep duration <6 h during both intervals, sleep duration <6 hours during the prepandemic interval, 6-7 h during the mid-pandemic interval, etc.). For these models, the reference groups were having recorded the longest mean duration (ie, >7 h) and highest sleep consistency (ie, >80) during both intervals. Assessment of wakefulness during time in bed, sleep onset, and sleep offset for associations with adverse mental health symptoms was outside the scope of this paper and therefore not included in multivariable analyses.
Standard demographic covariates included sex, age, combined race and ethnicity, highest education attainment, and employment status. Additional covariates included Census region to adjust for potential regional confounding related to COVID-19 prevalence and associated government-imposed movement restrictions, as well as characteristics associated with mental health disparities—unpaid caregiver role,
Mental health, substance use, and suicidal ideation among unpaid caregivers of adults in the United States during the COVID-19 pandemic: Relationships to age, race/ethnicity, employment, and caregiver intensity.
Mental Health Among Parents of Children Aged <18 Years and Unpaid Caregivers of Adults During the COVID-19 Pandemic - United States, December 2020 and February-March 2021.
Variables were identified a priori based on biologic plausibility and relevance to the study hypotheses. Statistical significance was set at 2-sided P × 2 <.05 and 95% confidence intervals were estimated at the 97.5% confidence level to account for 2 comparisons (Bonferroni adjustment).
All calculations were performed in Python version 3.7.8 (Python Software Foundation) and R version 4.0.2 (The R Project for Statistical Computing) using the R survey package version 3.29. Detailed methods are in the Supplement.
Results
Sample characteristics
During June 24-30, 2020, 20,717 of 139,237 eligible invited U.S. WHOOP users aged 18 years or older completed Internet-based surveys (response rate, 14.9%). Overall, 4912 (23.7%) participants recorded ≥70% nocturnal sleep episodes throughout all 3 study intervals (prepandemic, acute pandemic onset, mid-pandemic) and were included in the primary analytic sample. Of these, 3845 (78.3%) completed the PHQ-4 to screen for symptoms of anxiety and depression and were included in the mental health subsample. The sample comprised 3471 (70.7%) male and 3802 (77.2%) non-Hispanic White (White) adults. Most participants were highly educated (4105 [83.6%] college-educated), employed (4417 [89.9%]), and reported high household income (eg, ≥USD$100,000, 3126 [65.5%]). Mean age was 39.7 ± 11.24 years. See eFigure for the survey flow and Table 1 for detailed participant characteristics.
Table 1Participant characteristics.
All participants
Did complete the PHQ-4
Did not complete PHQ-4
Chi-square test for difference between samples
unweighted n (%)
unweighted n (%)
unweighted n (%)
P
Total Participants
4912
(100)
3845
(78.0)
1067
(22.0)
-
Sex
Female
1441
(29.3)
1187
(30.9)
254
(23.8)
0.0001
Male
3471
(70.7)
2658
(69.1)
813
(76.2)
Age group in years
18-29
981
(20.0)
692
(18.0)
289
(27.1)
<0.0001
30-44
2357
(48.0)
1827
(47.5)
530
(49.7)
45-64
1460
(29.7)
1221
(31.8)
239
(22.4)
≥65
113
(2.3)
105
(2.7)
8
(0.7)
Race and ethnicity
White, non-Hispanic
3802
(77.4)
3062
(79.6)
740
(69.4)
<0.0001
Black, non-Hispanic
93
(1.9)
72
(1.9)
21
(2.0)
Asian, non-Hispanic
174
(3.5)
122
(3.2)
52
(4.9)
Other race or races, non-Hispanic
147
(3.0)
115
(3.0)
32
(3.0)
Hispanic or Latino, any race or races
375
(7.6)
271
(7.0)
104
(9.7)
Unknown
321
(6.5)
203
(5.3)
118
(11.1)
U.S. Census region
Northeast
1211
(24.7)
942
(24.5)
269
(25.2)
>0.99
Midwest
780
(15.9)
601
(15.6)
179
(16.8)
South
1588
(32.3)
1244
(32.4)
344
(32.2)
West
1333
(27.1)
1058
(27.5)
275
(25.8)
2019 household income (USD)
<25,000
114
(2.3)
79
(2.1)
35
(3.3)
<0.0001
25,000-49,999
286
(5.8)
203
(5.3)
83
(7.8)
50,000-99,999
876
(17.8)
681
(17.7)
195
(18.3)
100,000-199,999
1503
(30.6)
1211
(31.5)
292
(27.4)
≥200,000
1713
(34.9)
1374
(35.7)
339
(31.8)
Unknown
420
(8.6)
297
(7.7)
123
(11.5)
Education
High school or less
118
(2.4)
82
(2.1)
36
(3.4)
0.029
Some college
663
(13.5)
498
(13.0)
165
(15.5)
Bachelor's degree
2353
(47.9)
1836
(47.8)
517
(48.5)
Professional degree
1752
(35.7)
1411
(36.7)
341
(32.0)
Unknown
26
(0.5)
18
(0.5)
8
(0.7)
Employment status
Employed nonessential
2441
(49.7)
1910
(49.7)
531
(49.8)
0.0004
Employed essential
1976
(40.2)
1551
(40.3)
425
(39.8)
Retired
151
(3.1)
135
(3.5)
16
(1.5)
Unemployed
203
(4.1)
157
(4.1)
46
(4.3)
Student only
141
(2.9)
92
(2.4)
49
(4.6)
Unpaid caregiver of adults
Yes
417
(8.5)
414
(10.8)
3
(0.3)
>0.99
No
3061
(62.3)
3046
(79.2)
15
(1.4)
Missing or unknown
1434
(29.2)
385
(10.0)
1049
(98.3)
Political ideology
Very liberal
669
(13.6)
555
(14.4)
114
(10.7)
<0.0001
Slightly liberal
1121
(22.8)
905
(23.5)
216
(20.2)
Neither liberal nor conservative
1223
(24.9)
941
(24.5)
282
(26.4)
Slightly conservative
999
(20.3)
803
(20.9)
196
(18.4)
Very conservative
348
(7.1)
263
(6.8)
85
(8.0)
Unknown or apolitical
552
(11.2)
378
(9.8)
174
(16.3)
Note. As caregiving status was assessed in the third phase of the survey, along with the PHQ-4, most participants who did not complete the PHQ-4 did not complete the question regarding caregiving status. The “missing or unknown” group was therefore excluded from the prevalence comparison between groups.
Overall, compared to the 6.95 ± 0.687 h or 416.9 ± 41.2 m mean sleep duration in the pre-pandemic interval, mean sleep duration was 0.25 h (95% CI, 0.237-0.270, P < .0001) or 15.2 m (95% CI, 14.2-16.2) longer in the acute pandemic interval, and 0.09 h (95% CI, 0.076-0.107, P < .0001) or 5.5m (95% CI, 4.5-6.4) longer in the mid-pandemic interval (Fig. 1A, eTable 1). In the overall sample, mean sleep duration remained significantly longer on weekend nights compared with weeknights (except for holidays), though the magnitude of difference dampened with time (Fig. 1A). Sleep consistency (0-100), which was generally lower on weekend nights compared to weeknights, increased during both COVID-19 intervals compared to the prepandemic interval, by 3.51 points (95% CI, 3.295-3.728 P < .0001) in the acute pandemic interval, and by 4.06 points (95% CI, 3.856-4.267, P < .0001) in the mid-pandemic interval (Fig. 1B, eTable 1). Wakefulness during time in bed increased by 0.05 h (95% CI, 0.031-0.074, P < .0001) or 3.2 m (95% CI, 0.03-4.4) in the acute pandemic interval compared to the prepandemic interval but did not between the mid-pandemic and prepandemic intervals (difference, 0.01 h, 95% CI, −0.020 to 0.0393, P > .99 or 0.6 m, 95% CI, −1.2 to 2.4) (Fig. 1C, eTable 1). Finally, sleep timing abruptly shifted to a later time (ie, delayed) immediately following the declaration of the pandemic by the World Health Organization on March 12, 2020, which preceded subsequent government-imposed movement restrictions in many U.S. states.
Over the next 4 weeks, mean sleep onset was 18.7 m later (95% CI, 17.4-20.0, P < .0001) and sleep offset was 36.6 m later (95% CI, 35.1-38.1, P < .0001) than during the prepandemic interval (Fig. 1D, eTable 1). The delay in sleep onset was sustained throughout the mid-pandemic interval (17.9 m [95% CI, 16.5-19.3, P < .0001]), while the delay in sleep offset attenuated to 25.2 m (95% CI, 23.6-26.7, P < .0001).
Fig. 1Sleep duration, consistency, wakefulness during time in bed, and timing, January 1, 2020-June 30, 2020. The vertical (A-C) or horizontal (D) dashed lines represent major public holidays (L to R) Martin Luther King Jr. Day, President's Day, Daylight Saving Time (March), the declaration of COVID-19 as a national emergency in the United States, and Memorial Day.
While in the overall sample we observed longer sleep duration, increased consistency of sleep timing, relatively stable wakefulness during time in bed, and delayed sleep timing during the COVID-19 pandemic intervals, a subset of participants experienced marked changes in the opposite directions (Fig. 2). We therefore examined deciles of participants with the highest-magnitude changes in sleep variables. The deciles with the highest-magnitude changes in sleep duration were lengthened and shortened by 0.77 h (95% CI, 0.742-0.794, P < .0001) or 46.1 m (95% CI, 44.5-47.7) and 0.50 h (95% CI, 0.522-0.470, P < .0001) or 29.8 m (95% CI, 31.3-28.2), respectively, while the deciles with the highest-magnitude changes in sleep consistency were increased and decreased by 12.85 points (95% CI, 12.480-13.214, P < .0001) and 4.41 points (95% CI, 4.720-4.099, P < .0001), respectively (eTable 2 ). Regarding sleep timing, the deciles with the largest delays in sleep onset and offset shifted later by 1.35 h (22:57 to 00:18, 95% CI, 1.288-1.414, P < .0001) or 81.1 m (95% CI, 77.3-84.9) and 1.65 h (06:40 to 08:19, 95% CI, 1.591-1.714, P < .0001) or 99.1 m (95% CI, 95.5-102.8), respectively. The deciles with the largest advances in sleep onset and offset shifted earlier by 0.56 h (07:12 to 06:43, 95% CI, 0.516-0.606, P < .0001) or 33.7 m (95% CI, 30.9-36.4) and 0.48 h (23:29 to 22:55, 95% CI, 0.434-0.523, P < .0001) or 28.7 m (95% CI, 26.0-31.4), respectively.
Fig. 2Heterogeneity in changes to sleep duration, consistency, wakefulness during time in bed, sleep onset, and sleep offset.
Table 2Adjusted odds ratios (aORs) for adverse mental health symptoms by pre-pandemic and pandemic sleep characteristics.
Anxiety or depression symptoms
New or increased substance use
Burnout symptoms
Total N
N (%) positive screen
aOR (95% CI)
P
Total N
N (%) positive screen
aOR (95% CI)
P
Total N
N (%) positive screen
aOR (95% CI)
P
Sleep duration—mean over prepandemic and pandemic intervals
Both >7 h (reference group)
1464
323 (22.1)
1.00 (Reference)
1720
376 (21.9)
1.00 (Reference)
1677
502 (29.9)
1.00 (Reference)
Both <6 h
180
44 (24.4)
1.75 (1.14, 2.69)
0.007
179
37 (20.7)
1.11 (0.69, 1.78)
>0.99
177
64 (36.2)
1.57 (1.07, 2.29)
0.016
<6 h to 6-7 h
122
23 (18.9)
1.12 (0.64, 1.98)
>0.99
121
29 (24.0)
1.21 (0.71, 2.04)
0.845
120
40 (33.3)
1.22 (0.77, 1.93)
0.663
<6 h to >7 h
4
0 (0.0)
NO ESTIMATE
4
1 (25.0)
NO ESTIMATE
4
1 (25.0)
NO ESTIMATE
Both 6-7 h
1058
212 (20.0)
1.30 (1.03, 1.65)
0.025
1052
249 (23.7)
1.21 (0.96, 1.52)
0.126
1033
358 (34.7)
1.39 (1.13, 1.70)
0.001
6-7 h to <6 h
90
24 (26.7)
1.96 (1.09, 3.54)
0.021
90
21 (23.3)
1.19 (0.65, 2.17)
>0.99
90
40 (44.4)
2.22 (1.32, 3.71)
0.001
6-7 h to >7 h
435
92 (21.1)
1.23 (0.90, 1.67)
0.265
435
90 (20.7)
0.96 (0.70, 1.31)
>0.99
421
143 (34.0)
1.22 (0.93, 1.6)
0.191
>7 h to <6 h
6
1 (16.7)
NO ESTIMATE
>0.99
6
3 (50.0)
NO ESTIMATE
6
6 (100)
NO ESTIMATE
>7 h to 6-7 h
216
36 (16.7)
0.94 (0.60, 1.46)
>0.99
213
50 (23.5)
1.08 (0.72, 1.64)
>0.99
206
54 (26.2)
0.86 (0.59, 1.26)
0.750
Sleep consistency—mean over pre-pandemic and pandemic intervals
Both >80 out of 100 (reference group)
595
87 (14.6)
1.00 (Reference)
588
92 (15.6)
1.00 (Reference)
570
153 (26.8)
1.00 (Reference)
Both <70
427
110 (25.8)
1.74 (1.19, 2.55)
0.002
421
131 (31.1)
2.17 (1.48, 3.19)
<0.001
415
180 (43.4)
1.77 (1.28, 2.45)
<0.001
<70 to 70-80
540
117 (21.7)
1.38 (0.95, 1.99)
0.101
537
128 (23.8)
1.38 (0.95, 1.99)
0.103
525
186 (35.4)
1.27 (0.94, 1.73)
0.158
<70 to >80
84
17 (20.2)
1.13 (0.57, 2.25)
>0.99
84
20 (23.8)
1.35 (0.69, 2.65)
0.643
79
22 (27.8)
0.88 (0.48, 1.62)
>0.99
Both 70-80
1106
223 (20.2)
1.34 (0.97, 1.85)
0.088
1102
259 (23.5)
1.46 (1.06, 2.01)
0.016
1080
363 (33.6)
1.22 (0.93, 1.60)
0.191
70-80 to <70
104
31 (29.8)
2.07 (1.17, 3.67)
0.009
104
29 (27.9)
1.66 (0.91, 3.03)
0.119
103
34 (33.0)
1.08 (0.63, 1.84)
>0.99
70-80 to >80
909
154 (16.9)
1.11 (0.79, 1.56)
0.954
906
177 (19.5)
1.17 (0.84, 1.63)
0.598
888
246 (27.7)
0.99 (0.75, 1.31)
>0.99
>80 to <70
2
1 (50.0)
NO ESTIMATE
2
1 (50.0)
NO ESTIMATE
2
0 (0.0)
NO ESTIMATE
>80 to 70-80
78
15 (19.2)
1.35 (0.66, 2.75)
0.700
76
19 (25.0)
1.62 (0.80, 3.30)
0.253
72
24 (33.3)
1.31 (0.71, 2.42)
0.649
Note. Scores ≥3 out of 6 on either the PHQ-2 or GAD-2 subscales of the PHQ-4 were considered positive screens for anxiety or depression symptoms. Affirmative answers to a question about having past-month new or increased substance use to cope with stress or emotions was considered positive screens for new or increased substance use. Scores ≥3 out of 5 on the single-item Mini-Z burnout measure were considered positive screens for burnout symptoms. Multivariable logistic regression models used to estimate odds ratios included the following covariates: sex, age, race and ethnicity, education attainment, employment status, Census region, unpaid caregiver status, diurnal preference, alcohol consumption, and physical activity. Estimates are not provided for outcomes with Total N <10 respondents. Bolded values are significant at 2-sided P × 2<0.05 and 95% confidence intervals were estimated at the 97.5% confidence level to account for 2 comparisons (Bonferroni adjustment).
Of 3845 participants who completed the PHQ-4, 755 (19.6%) screened positive for anxiety or depression symptoms, 1208 (32.4%) screened positive for burnout symptoms, and 856 (22.4%) reported new or increased substance use to cope with stress or emotions (Table 1). Multivariable analysis including demographic variables, sleep, physical activity, and alcohol use revealed that sleep duration and consistency were associated with differences in mental health outcomes (Table 2).
Compared with participants who slept >7 h in the prepandemic and pandemic intervals, participants who slept <6 h in both intervals had higher odds of anxiety or depression symptoms (aOR, 1.75 [95% CI, 1.14-2.69] P = .007) and burnout symptoms (aOR, 1.57 [95% CI, 1.07-2.29] P = .016), as did those who slept 6-7 h and those who experienced a decrease in sleep duration to <6 h during the pandemic from 6-7 h in the prepandemic interval (eg, burnout symptoms, aOR, 2.22 [95% CI, 1.32-3.71] P = .001).
Compared with participants with sleep consistency >80 in both intervals, participants with sleep consistency <70 in both intervals had higher odds of all assessed adverse mental and behavioral health symptoms (eg, new or increased substance use, aOR, 2.17 [95% CI, 1.48-3.19] P < .0001). Odds of new or increased substance use were also higher among participants with sleep consistency of 70-80 during both intervals (aOR, 1.46 [95% CI, 1.06-2.01] P = .016), and odds of anxiety or depression symptoms were higher among participants whose sleep consistency decreased from 70-80 in the prepandemic interval to <70 in the pandemic interval (aOR, 2.07 [95% CI, 1.17-3.67] P = .0009). Odds of adverse mental or behavioral health symptoms were not higher for participants with decreases in sleep duration or sleep consistency who had optimal duration (>7 h) or consistency (>80) in the prepandemic interval.
Discussion
Among nearly 5000 active users of an objective sleep wearable with data preceding the COVID-19 pandemic, we found acutely increased sleep duration and delayed sleep timing in the first month during which stringent mitigation policies were implemented widely across the U.S., consistent with national and global literature.
Estimated sleep duration before and during the COVID-19 pandemic in major metropolitan areas on different continents: observational study of smartphone app data.
Changes in health promoting behavior during COVID-19 physical distancing: utilizing wearable technology to examine trends in sleep, activity, and cardiovascular indicators of health.
we also found abrupt and sustained increases in sleep consistency during the pandemic. Across the sample, the magnitude of the increase in mean sleep duration decreased gradually in the subsequent 2 months, as mean sleep offset returned to near prepandemic times, while delayed sleep onset persisted.
Adverse mental and behavioral health symptoms, including anxiety or depression symptoms, new or increased substance use to cope with stress or emotions, and burnout symptoms were associated with pre-pandemic sleep deficiency and inconsistent sleep, but not acute decreases in sleep duration or sleep consistency experienced during the pandemic. Recent past sleep-wake behavior was therefore associated with comparatively better mental health during the pandemic interval with profound lifestyle changes, such as the stringent social and behavioral interventions (eg, stay-at-home orders, work-from-home directives). Alternatively, given bidirectional relationships between sleep and mental health,
persistently unhealthy sleep patterns in some individuals might have been associated with existing mental health conditions. Independent of the directionality, these findings provide further evidence of the important role of sleep during the pandemic as outlined in the National Sleep Foundation Position Statement,
and support continued investigation of behavioral interventions to improve sleep duration and the consistency of sleep timing as modifiable risk factors
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia.
modifiable mental health risk factors are of critical importance. Insufficient sleep duration and inconsistent sleep timing are highly prevalent in modern society.
Estimated sleep duration before and during the COVID-19 pandemic in major metropolitan areas on different continents: observational study of smartphone app data.
Changes in health promoting behavior during COVID-19 physical distancing: utilizing wearable technology to examine trends in sleep, activity, and cardiovascular indicators of health.
Our unique dataset linking mental health and objective, high-resolution prepandemic sleep-wake data enhances our understanding of relationships between sleep and mental health.
Consensus Conference Panel Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.
Furthermore, improving sleep may have benefits for other elements of health, including general health, cardiovascular and immune function, and metabolic performance.
Analysis of participants with high-magnitude changes to sleep measures revealed disparate changes to sleep-wake behavior during the pandemic, which could be explored through trajectory analyses in future work.
Strengths and limitations
Strengths of this study include the use of objective sleep measures, inclusion of prepandemic comparator sleep data, recruitment of a large sample, use of psychometrically validated mental health screening instruments, and inclusion of demographic and lifestyle-related variables (ie, physical activity, alcohol consumption) in multivariable models assessing for associations with a comprehensive set of sleep variables (ie, duration, timing, consistency).
Limitations of this study include the 14.9% response rate, a lack of prepandemic comparator mental health data, nonrandom recruitment methods, uncertainties about objective measurement of sleep in this population and setting, and potential seasonal influences on sleep and mood.
Regarding the relatively low response rate, nonresponse could give rise to sampling bias if nonresponse were unequal among participants with respect to sleep and mental health measures.
Regarding reliance upon cross-sectional mental health measures, doing so precludes a causal interpretation of mental health findings, especially given evidence of bidirectional relationships with sleep.
The bidirectional relationship between sleep duration and depression in community-dwelling middle-aged and elderly individuals: evidence from a longitudinal study.
Additional studies are warranted to elucidate the directionality of these relationships. Moreover, some stressors might not have been captured, including employment disruptions, health declines, and SARS-CoV-2 infection or COVID-19 illness.
Regarding nonrandom recruitment, most sample participants were male, highly educated, employed, and reported higher-than-national-average household income. Given that income was highly predictive of changes in mobility during the pandemic, with wealthy areas exhibiting larger mobility reductions,
this sample may over-represent effects on sleep of stay-at-home orders. Moreover, there is evidence that social determinants of mental and sleep health include more assets, such as income and employment requirements (eg, remote-work options, essential-worker responsibilities).
Sample-level prevalence estimates for anxiety or depression symptoms were considerably lower in this sample (19.6%) than in a largescale, demographically representative sample evaluated using the same screening instrument during the same time interval (30.9%),
which might reflect demographic and socioeconomic differences in sample composition. However, multivariable analysis odds ratio estimates (not shown) suggest that most of the relative demographic differences in adverse mental health symptoms (eg, by sex, age, and diurnal preference) were consistent with those of the general population.
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia.
Regarding objective sleep-wake measurement, although WHOOP has demonstrated high levels of agreement for sleep-wake with gold-standard polysomnography among young, healthy adults in laboratory assessments,
its performance in free-living conditions within a more heterogeneous sample is less known, and participants did not complete daily sleep diaries to support sleep onset and offset measurements. Furthermore, the performance of WHOOP relative to polysomnography on some variables (sleep onset, sleep offset, wakefulness during time in bed) has not been reported. Given that WHOOP is a subscription tracker of sleep and fitness, participants may have been more knowledgeable about and motivated to pursue optimal sleep health and fitness than the U.S. adult population, which could limit the generalizability of findings.
Finally, it is possible that sleep and mental health responses to the onset of a pandemic may vary with season and be influenced by daylight savings time changes; however, 2019 and 2020 data on time in bed and sleep timing from both Ong et al. based on data from 20 countries (with variable daylight savings time presence and timing)
Changes in health promoting behavior during COVID-19 physical distancing: utilizing wearable technology to examine trends in sleep, activity, and cardiovascular indicators of health.
indicate that the magnitude of changes to sleep-wake behavior observed in the months after the COVID-19 pandemic were not observed the year before. For example, in 2019, time in bed was slightly shorter during March 10 through May 15 compared to January 1 through March 9, 2019 (by 0.05 ± 0.003 h), and sleep offset time did not differ significantly between the intervals. Comparing the same intervals in 2020, time in bed was considerably longer during March 10 through May 15 (by 0.24 ± 0.003 h), and sleep offset was significantly later (by 29 ± 1 m).
Conclusions
As policymakers grapple with decisions about stringent mitigation measures during future waves of SARS-CoV-2 or other pathogens, community institutions, healthcare providers, and public health agencies should consider the potential roles of sleep and circadian rhythms in mitigating potential mental health consequences. Findings from this study of U.S. adult users of a wearable device support sleep duration and consistency of sleep timing as potential modifiable risk factors for adverse mental health during stressful life events. Future research should (1) explore the directionality and impact of prolonged physiological and behavioral changes observed following SARS-CoV-2 infection on mental health (2) determine predictors of counter-sample sleep patterns (eg, reduced sleep duration, less consistent sleep timing) and (3) evaluate public health programs with elements informed by sleep and circadian principles as primary prevention strategies for adverse mental health outcomes.
Funding
There was no specific funding for survey data collection. Mr Czeisler was supported in part by a 2020 Australian-American Fulbright Scholarship funded by The Kinghorn Foundation, and by a grant from WHOOP, Inc., to Monash University acting through its Faculty of Medicine, Nursing and Health Sciences. Dr Czeisler is the incumbent of an endowed professorship provided to Harvard University by Cephalon, Inc.
Declaration of conflict of interest
Mr Czeisler and Drs Weaver, Czeisler, Howard, and Rajaratnam reported receiving a grant from the CDC Foundation with funding from BNY Mellon, a grant from WHOOP, Inc., and a gift from Hopelab, Inc. Mr Czeisler reported having received a grant from the Australian-American Fulbright Commission administered through a 2020 to 2021 Fulbright Scholarship funded by The Kinghorn Foundation and having received personal fees from Vanda Pharmaceuticals. Ms Capodilupo is a paid employee of and has equity interest in WHOOP, Inc., and has equity interest in ARCHANGELS. Dr Weaver reported consulting fees from National Sleep Foundation and the University of Pittsburgh. Dr Czeisler reported receiving grants to support The COVID-19 Outbreak Public Evaluation (COPE) Initiative and grants from Brigham and Women's Physician's Organization during the conduct of the study; being a paid consultant to or speaker for Ganésco, Institute of Digital Media and Child Development, Klarman Family Foundation, M. Davis and Co, Physician's Seal, Samsung Group, State of Washington Board of Pilotage Commissioners, Tencent Holdings, Teva Pharma Australia, and Vanda Pharmaceuticals, in which Dr Czeisler holds an equity interest; receiving travel support from Aspen Brain Institute, Bloomage International Investment Group, UK Biotechnology and Biological Sciences Research Council, Bouley Botanical, Dr Stanley Ho Medical Development Foundation, Illuminating Engineering Society, National Safety Council, Tencent Holdings, and The Wonderful Co; receiving institutional research and/or education support from Cephalon, Mary Ann and Stanley Snider via Combined Jewish Philanthropies, Harmony Biosciences, Jazz Pharmaceuticals PLC, Johnson and Johnson, Neurocare, Peter Brown and Margaret Hamburg, Philips Respironics, Regeneron Pharmaceuticals, Regional Home Care, Teva Pharmaceuticals Industries, Sanofi S.A., Optum, ResMed, San Francisco Bar Pilots, Schneider National, Serta, Simmons Betting, Sysco, Vanda Pharmaceuticals; being or having been an expert witness in legal cases, including those involving Advanced Power Technologies; Aegis Chemical Solutions; Amtrak; Casper Sleep; C and J Energy Services; Complete General Construction; Dallas Police Association; Enterprise Rent-A-Car; Steel Warehouse Co; FedEx; Greyhound Lines; Palomar Health District; PAR Electrical, Product, and Logistics Services; Puckett Emergency Medical Services; South Carolina Central Railroad Co; Union Pacific Railroad; UPS; and Vanda Pharmaceuticals; serving as the incumbent of an endowed professorship provided to Harvard University by Cephalon; and receiving royalties from McGraw Hill and Philips Respironics for the Actiwatch-2 and Actiwatch Spectrum devices. Dr Czeisler's interests were reviewed and are managed by the Brigham and Women's Hospital and Mass General Brigham in accordance with their conflict-of-interest policies. Dr Rajaratnam reported receiving institutional consulting fees from CRC for Alertness, Safety, and Productivity; Teva Pharmaceuticals; Vanda Pharmaceuticals; Circadian Therapeutics; BHP Billiton; and Herbert Smith Freehills; receiving grants from Teva Pharmaceuticals and Vanda Pharmaceuticals; and serving as chair for the Sleep Health Foundation outside the submitted work. Dr Howard reports receiving institutional consulting fees from Teva Pharmaceuticals, Biogen and Sanofi; and equipment to support research from Optalert and Philips Respironics outside the submitted work. No other potential conflicts of interest were reported.
Acknowledgments
The authors thank Thomas Rand (WHOOP, Inc.) for coding the survey onto the WHOOP interface, as well as Rebecca Robbins, PhD (Brigham and Women's Hospital, Harvard Medical School), Laura K Barger, PhD (Brigham and Women's Hospital, Harvard Medical School), and Elise R Facer-Childs, PhD (Monash University) for their contributions to the initial survey instrument for The COPE Initiative. MÉC gratefully acknowledges funding by The Kinghorn Foundation through a 2020 to 2021 Australian-American Fulbright Scholarship.
Estimated sleep duration before and during the COVID-19 pandemic in major metropolitan areas on different continents: observational study of smartphone app data.
Changes in health promoting behavior during COVID-19 physical distancing: utilizing wearable technology to examine trends in sleep, activity, and cardiovascular indicators of health.
Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia.
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.
Too long, too short, or too variable? Sleep intraindividual variability and its associations with perceived sleep quality and mood in adolescents during naturalistically unconstrained sleep.
Objectively assessed sleep variability as an acute warning sign of suicidal ideation in a longitudinal evaluation of young adults at high suicide risk.
Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.
Mental health, substance use, and suicidal ideation among unpaid caregivers of adults in the United States during the COVID-19 pandemic: Relationships to age, race/ethnicity, employment, and caregiver intensity.
Mental Health Among Parents of Children Aged <18 Years and Unpaid Caregivers of Adults During the COVID-19 Pandemic - United States, December 2020 and February-March 2021.
The bidirectional relationship between sleep duration and depression in community-dwelling middle-aged and elderly individuals: evidence from a longitudinal study.
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