Abstract
Context and purpose
The literature suggests that severe sleep loss of more than a few hours a night decreases
glucose tolerance and insulin sensitivity. The aim of this study was to determine
whether moderate sleep restriction had similar effects.
Methods
Fifteen healthy non-obese (body mass index = 24.5 ± 3.4 kg/m2) young adults (20.6 ± 1.3 years) completed two 2-hour oral glucose tolerance tests
(OGTTs): one was after 3 days of time-in-bed restriction by 1 to 3 hours each night,
and the other was after 3 days of ad libitum sleep. Glucose and insulin concentrations
during OGTT and fasting glucagon and cortisol concentrations were determined. The
homeostasis model of insulin resistance, Matsuda index, and the quantitative insulin
sensitivity check index were calculated.
Results
The total time-in-bed during the sleep restriction and the ad libitum phase was 5.98
± 0.76 and 7.98 ± 0.54 hours/day, and total sleep time was 5.16 ± 0.49 and 6.65 ±
0.64 hours/day, respectively. Glucose concentrations before and 30, 60, 90, and 120
minutes after consumption of glucose and area under the curve were not different for
the 2 OGTTs (P > .10 for all). Insulin concentration at fasting and area under the curve during
the OGTT were significantly higher (P = .034 and .038, respectively) after restricted sleep than after ad libitum sleep.
Fasting glucagon concentration was also higher (P = .003). The homeostasis model of insulin resistance, Matsuda index, and quantitative
insulin sensitivity check index all suggested decreased insulin sensitivity after
restricted sleep.
Conclusion
Short-term moderate sleep restriction reduced insulin sensitivity compared to ad libitum
sleep in this group of healthy young adults.
Keywords
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Article info
Publication history
Published online: January 11, 2016
Accepted:
November 18,
2015
Received in revised form:
October 28,
2015
Received:
August 28,
2015
Identification
Copyright
© 2016 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
