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Short-term moderate sleep restriction decreases insulin sensitivity in young healthy adults

Published:January 11, 2016DOI:https://doi.org/10.1016/j.sleh.2015.11.004

      Abstract

      Context and purpose

      The literature suggests that severe sleep loss of more than a few hours a night decreases glucose tolerance and insulin sensitivity. The aim of this study was to determine whether moderate sleep restriction had similar effects.

      Methods

      Fifteen healthy non-obese (body mass index = 24.5 ± 3.4 kg/m2) young adults (20.6 ± 1.3 years) completed two 2-hour oral glucose tolerance tests (OGTTs): one was after 3 days of time-in-bed restriction by 1 to 3 hours each night, and the other was after 3 days of ad libitum sleep. Glucose and insulin concentrations during OGTT and fasting glucagon and cortisol concentrations were determined. The homeostasis model of insulin resistance, Matsuda index, and the quantitative insulin sensitivity check index were calculated.

      Results

      The total time-in-bed during the sleep restriction and the ad libitum phase was 5.98 ± 0.76 and 7.98 ± 0.54 hours/day, and total sleep time was 5.16 ± 0.49 and 6.65 ± 0.64 hours/day, respectively. Glucose concentrations before and 30, 60, 90, and 120 minutes after consumption of glucose and area under the curve were not different for the 2 OGTTs (P > .10 for all). Insulin concentration at fasting and area under the curve during the OGTT were significantly higher (P = .034 and .038, respectively) after restricted sleep than after ad libitum sleep. Fasting glucagon concentration was also higher (P = .003). The homeostasis model of insulin resistance, Matsuda index, and quantitative insulin sensitivity check index all suggested decreased insulin sensitivity after restricted sleep.

      Conclusion

      Short-term moderate sleep restriction reduced insulin sensitivity compared to ad libitum sleep in this group of healthy young adults.

      Keywords

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      References

        • Gottlieb D.J.
        • Punjabi N.M.
        • Newman A.B.
        • et al.
        Association of sleep time with diabetes mellitus and impaired glucose tolerance.
        Arch Intern Med. 2005; 165: 863-867
        • Buxton O.M.
        • Marcelli E.
        Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States.
        Soc Sci Med. 2010; 71: 1027-1036
        • Ayas N.T.
        • White D.P.
        • Al-Delaimy W.K.
        • et al.
        A prospective study of self-reported sleep duration and incident diabetes in women.
        Diabetes Care. 2003; 26: 380-384
        • Yaggi H.K.
        • Araujo A.B.
        • McKinlay J.B.
        Sleep duration as a risk factor for the development of type 2 diabetes.
        Diabetes Care. 2006; 29: 657-661
        • Cappuccio F.P.
        • D'Elia L.
        • Strazzullo P.
        • Miller M.A.
        Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis.
        Diabetes Care. 2010; 33: 414-420
        • Beihl D.A.
        • Liese A.D.
        • Haffner S.M.
        Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort.
        Ann Epidemiol. 2009; 19: 351-357
        • Chaput J.P.
        • Despres J.P.
        • Bouchard C.
        • Astrup A.
        • Tremblay A.
        Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study.
        Sleep Med. 2009; 10: 919-924
        • Rafalson L.
        • Donahue R.P.
        • Stranges S.
        • et al.
        Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study.
        Ann Epidemiol. 2010; 20: 883-889
        • Heianza Y.
        • Kato K.
        • Fujihara K.
        • et al.
        Role of sleep duration as a risk factor for type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study.
        Diabet Med. 2014; 31: 1363-1367
        • Liu A.
        • Kushida C.A.
        • Reaven G.M.
        Habitual shortened sleep and insulin resistance: an independent relationship in obese individuals.
        Metab Clin Exp. 2013; 62: 1553-1556
        • Donga E.
        • van Dijk M.
        • van Dijk J.G.
        • et al.
        A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects.
        J Clin Endocrinol Metab. 2010; 95: 2963-2968
        • Spiegel K.
        • Leproult R.
        • Van Cauter E.
        Impact of sleep debt on metabolic and endocrine function.
        Lancet. 1999; 354: 1435-1439
        • Reynolds A.C.
        • Dorrian J.
        • Liu P.Y.
        • et al.
        Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men.
        PLoS One. 2012; 7e41218
        • van Leeuwen W.M.
        • Hublin C.
        • Sallinen M.
        • Harma M.
        • Hirvonen A.
        • Porkka-Heiskanen T.
        Prolonged sleep restriction affects glucose metabolism in healthy young men.
        Int J Endocrinol. 2010; 2010108641
        • Schmid S.M.
        • Hallschmid M.
        • Jauch-Chara K.
        • et al.
        Disturbed glucoregulatory response to food intake after moderate sleep restriction.
        Sleep. 2011; 34: 371-377
        • Broussard J.L.
        • Ehrmann D.A.
        • Van Cauter E.
        • Tasali E.
        • Brady M.J.
        Impaired insulin signaling in human adipocytes after experimental sleep restriction.
        Ann Intern Med. 2012; 157: 549-557
        • Buxton O.M.
        • Pavlova M.
        • Reid E.W.
        • Wang W.
        • Simonson D.C.
        • Adler G.K.
        Sleep restriction for 1 week reduces insulin sensitivity in healthy men.
        Diabetes. 2010; 59: 2126-2133
        • Gonzalez-Ortiz M.
        • Martinez-Abundis E.
        • Balcazar-Munoz B.R.
        • Pascoe-Gonzalez S.
        Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects.
        Diabetes Nutr Metab. 2000; 13: 80-83
        • VanHelder T.
        • Symons J.D.
        • Radomski M.W.
        Effects of sleep deprivation and exercise on glucose tolerance.
        Aviat Space Environ Med. 1993; 64: 487-492
        • Nedeltcheva A.V.
        • Kessler L.
        • Imperial J.
        • Penev P.D.
        Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance.
        J Clin Endocrinol Metab. 2009; 94: 3242-3250
        • Zielinski M.R.
        • Kline C.E.
        • Kripke D.F.
        • Bogan R.K.
        • Youngstedt S.D.
        No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers.
        J Sleep Res. 2008; 17: 412-419
        • Shan Z.
        • Ma H.
        • Xie M.
        • et al.
        Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies.
        Diabetes Care. 2015; 38: 529-537
        • Gangwisch J.E.
        • Heymsfield S.B.
        • Boden-Albala B.
        • et al.
        Sleep duration as a risk factor for diabetes incidence in a large US sample.
        Sleep. 2007; 30: 1667-1673
        • Youngstedt S.D.
        • Kripke D.F.
        • Kline C.E.
        • Zielinski M.R.
        • Bogan R.K.
        Lack of impairment in glucose tolerance: support for further investigation of sleep restriction in older long sleepers.
        J Sleep Res. 2010; 19: 116-117
        • Sleep in America
        National Sleep Foundation.
        2010
        • Killick R.
        • Hoyos C.M.
        • Melehan K.L.
        • Dungan G.C.
        • Poh J.
        • Liu P.Y.
        Metabolic and hormonal effects of “catch-up” sleep in men with chronic, repetitive, lifestyle-driven sleep restriction.
        Clin Endocrinol (Oxf). 2015; 14 ([Epub 2015 Feb 14])
        • Buysse D.J.
        • Reynolds Iii C.F.
        • Monk T.H.
        • Berman S.R.
        • Kupfer D.J.
        The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research.
        Psychiatry Res. 1989; 28: 193-213
        • Sadeh A.
        • Sharkey K.M.
        • Carskadon M.A.
        Activity-based sleep-wake identification: an empirical test of methodological issues.
        Sleep. 1994; 17: 201-207
        • Johns M.W.
        A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
        Sleep. 1991; 14: 540-545
        • Tai M.M.
        A mathematical model for the determination of total area under glucose tolerance and other metabolic curves.
        Diabetes Care. 1994; 17: 152-154
        • Matthews D.R.
        • Hosker J.P.
        • Rudenski A.S.
        • Naylor B.A.
        • Treacher D.F.
        • Turner R.C.
        Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
        Diabetologia. 1985; 28: 412-419
        • Katz A.
        • Nambi S.S.
        • Mather K.
        • et al.
        Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.
        J Clin Endocrinol Metab. 2000; 85: 2402-2410
        • Matsuda M.
        • DeFronzo RA. XR.A.
        Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
        Diabetes Care. 1999; 22: 1462-1470
        • Bosy-Westphal A.
        • Hinrichs S.
        • Jauch-Chara K.
        • et al.
        Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women.
        Obes Facts. 2008; 1: 266-273
        • Schmid S.M.
        • Jauch-Chara K.
        • Hallschmid M.
        • Schultes B.
        Mild sleep restriction acutely reduces plasma glucagon levels in healthy men.
        J Clin Endocrinol Metab. 2009; 94: 5169-5173
        • Robertson M.D.
        • Russell-Jones D.
        • Umpleby A.M.
        • Dijk D.-J.
        Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men.
        Metabolism. 2013; 62: 204-211
        • Guyon A.B.M.
        • Morselli L.L.
        • Tasali E.
        • et al.
        Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men.
        J Clin Endocrinol Metab. 2014; 99: 2861-2868
        • Plat L.
        • Leproult R.
        • L'Hermite-Baleriaux M.
        • et al.
        Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning.
        J Clin Endocrinol Metab. 1999; 84: 3082-3092
        • Leproult R.
        • Copinschi G.
        • Buxton O.
        • Van Cauter E.
        Sleep loss results in an elevation of cortisol levels the next evening.
        Sleep. 1997; 20: 865-870
        • Omisade A.
        • Buxton O.M.
        • Rusak B.
        Impact of acute sleep restriction on cortisol and leptin levels in young women.
        Physiol Behav. 2010; 99: 651-656
        • Broussard J.L.
        • Ehrmann D.A.
        • Van Cauter E.
        • Tasali E.
        • Brady M.J.
        Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.
        Ann Intern Med. 2012; 157: 549-557
        • Broussard J.
        • Chapotot F.
        • Abraham V.
        • et al.
        Sleep restriction increases free fatty acids in healthy men.
        Diabetologia. 2015; 58: 791-798
        • Buxton O.M.
        • Cain S.W.
        • O’Connor S.P.
        • et al.
        Metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption.
        Sci Transl Med. 2012; 4 ([129ra43-ra43])
        • Spiegel K.
        • Knutson K.
        • Leproult R.
        • Tasali E.
        • Cauter E.V.
        Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes.
        J Appl Physiol. 2005; 99: 2008-2019